Alkhurma hemorrhagic fever virus (AHFV) is an agent of a viral hemorrhagic fever in Saudi Arabia causing because of sheeps, camel, goats and characterized serologically and genetically as a variant genotype of Forest disease virus. Since viral diagnosis and vaccine development may be hindered by genetic diversity, this study was intended to address AHFV genetic heterogeneity
Clinical manifestations include fever, headache, retroorbital pain, joint pain, generalized muscle pain, anorexia and vomiting associated with leukopenia, thrombocytopenia, and elevated levels of liver enzymes and some patients had clinical symptoms of hemorrhagic fever or encephalitis.
Evaluation of divergence times showed that AHFV and KFDV ancestral lineage diverged 66?177 years ago, and the diversity observed within the studied AHFV strains reflected a 4 to 72 year period of evolution. 11 human isolates of AHFV, obtained in a 5-year period, were studied and 5 patients of 24 infected and died for a 25% fatality rate.