Taenia Crassiceps

Taenia crassiceps is a member of the Taenia genus. It is a tapeworm. It is related to Taenia solium, the pork tapeworm, and to Taenia saginata, the beef tapeworm. Its larvae eat tiny holes in the human retina, eventually detaching it. The life cycle is when an adult lays eggs inside a wild canine. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from Taenia crassiceps are important determinant for protection of host form parasitic infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of antigen protein having 72 amino acids, which shows 64 nonamers. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Taenia crassiceps. Trichinella species are the smallest nematode parasite of humans; have an unusual life cycle and are one of the most widespread and clinically important parasites in the world. The small adult worms mature in the intestines of an intermediate host such as a pig. Taenia crassiceps antigen peptides are most suitable for subunit vaccine development because with single epitope; the immune response can be generated in large population. This approach is based on the phenomenon of cross-protection; whereby infected with a mild strain and is protected against a more severe strain of the same. The phenotype of the resistant transgenic hosts includes fewer centers of initial infection; a delay in symptom development; and low accumulation.

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Last date updated on April, 2024