Gene Symbol

Protein

Features

Fold- change

1

CLRN3

Clarin 3

Transmembrane protein not well characterized

13

2

SFRP4

Secreted frizzled-related protein 4

Overexpressed in colorectal cancers

11

3

SPOCK1

Testican-1

Plasma proteoglycan with unknown function

10

4

P4HA3

Procollagen-proline, 2-oxoglutarate 4-dioxygenase

Enzyme not well studied

9

5

TMEM158

Transmembrane protein 158

Associated with colorectal carcinogenesis

9

6

CHRDL2

Chordin-like 2

Overexpressed in breast, lung and colon tumors

7

7

GREM1

Gremlin 1

Overexpressed in epithelial tumors

5

8

ASPN

Asporin

Novel marker identified in breast cancer

10

9

ASH1L

Ash1 (absent, small, or homeotic)-like

Reported as therapeutic target in lung cancer

7

10

DOCK4

Dedicator of cytokinesis 4

Known to play crucial role in cell migration

7

11

HOXA11S

Homeo box A11, antisense

Non coding RNA not well characterized

6

12

PPAPDC1A

Phosphatidic acid phosphatase type 2 domain containing 1A

Upregulated in breast cancer

6

13

DPYSL3

Dihydropyrimidinase-like 3

Phosphoprotein involved in neuroblastoma

5

14

COMP

Cartilage oligomeric matrix protein

Overexpressed in oral submucous fibrosis

6

15

LPPR4

Plasticity related gene 1

Membrane protein not well characterized

5

Table 2: A partial list of novel genes upregulated in gastric adenocarcinoma.