Pro#

Pathways Involved

Reactions Related

22

glucose metabolism

PFKFB1 dimer+ATP=phosphor PFKFB1 dimer+ADP

lipid digestion,mobilization, and transport

perilipin+ATP=phosphorylated perilipin+ADP; hormone sensitive lipase+ATP=phosphorylated hormone sensitive lipase+ADP

hemostasis

opioid signalling

PKA tetramer + 3’,5’-cyclic AMP = PKA catalytic subunit + cAMP : PKA regulatory subunit; ATP+CREB=ADP+phosphor-CREB

NGF signalling

ATP+CREB=ADP+phosphor-CREB

glucagon signaling

ChREBP protein+ATP= pChREBP(Thr 666)+ADP;
pChREBP(Thr 666)+ATP= pChREBP(Ser 196, Thr 666)+ADP;
PFKFB1 dimer+ATP=phosphor PFKFB1 dimer+ADP

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

regulation of insulin secretion

Rap1 signalling

Rap1 GTPase-activating protein 2+ATP=p(S7)-Rap1 GTPase- activating protein 2+ADP

regulation of water balance by renal aquaporins

aquaporin-2 tetramer+ATP=phosphorylated aquaporin-2 tetramer+ADP

28

megakaryocyte development and platelet production(hemostasis)

GTP+AMP = GDP+ADP

31

Apoptosis

ZO-2→proteolytically cleaved ZO-2(acted by caspase)