| Term |
Count1 |
P value2 |
Fold change3 |
Benjamini4 |
| Biological process (ES5=9.68) |
| Regulation of immune system |
21 |
1.5E-14 |
9.7 |
2.2E-11 |
| Immune system |
30 |
2.1E-14 |
5.4 |
1.6E-11 |
| Molecular function (ES=10.27) |
| Receptor binding |
28 |
6.4E-15 |
6.2 |
1.8E-12 |
| Cytokine activity |
12 |
3.4E-09 |
12.0 |
4.7E-07 |
| Growth factor activity |
11 |
7.3E-09 |
13.0 |
5.1E-07 |
| Pathway (ES=3.70) |
| Cytokine-cytokine receptor interaction |
16 |
6.0E-08 |
5.5 |
3.8E-06 |
| Hematopoietic cell lineage |
9 |
3.1E-06 |
9.5 |
9.8E-05 |
| Jak-STAT signaling pathway |
10 |
3.4E-05 |
5.9 |
4.4E-04 |
1Indicates the number of genes involved in individual GO terms. 2Defines the significance of a GO term enrichment with a modified Fisher’s exact test (EASE score),
denoting if the term is over or under represented (if P ≤ 0.05, then terms are overrepresented). 3Statistical threshold for GO term selection (FC > 2). 4To globally correct
enrichment P-values to control family-wide false discovery rate at Benjamini ≤ 0.0004. 5Enrichment score (ES) was used to rank overall importance (enrichment) of GO
terms. |
