| |
Protein |
Location |
Biological function |
| Synaptic |
Snap25 (Synaptosomal-associated 25kD protein) |
Cytoplasm, plasma membrane, cell junction synaptosome |
Neurotransmitter uptake and secretion; synaptic transmission; synaptic vesicle docking during exocytosis; regulation of insulin secretion. |
| |
Cltb (Clathrin, light chain B) |
Plasma membrane |
Intracellular protein/receptor transport; vesicle-mediated transport. |
| |
Snca (Synuclein α) |
nucleus, cytoplasm, plasma membrane |
Integration of presynaptic signaling and membrane trafficking; regulation of dopamine secretion; negative regulation of mono-oxygenase activity; response to interferon gamma; negative regulation of histone acetylation. |
| Metabolic |
Hk1 (Hexokinase type-I, chain B) |
Mitochondria, cytoplasm |
Glycolysis; anti-apoptosis; energy and glucose metabolism. |
| |
Gapdh (Glyceraldehyde-3-phosphate
dehydrogenase) |
Cytoplasm,nucleus,membrane, perinuclear region |
Glucose metabolism; glycolysis; oxidation reduction; apoptosis; energy metabolism. |
| |
Psmb2 (Proteasome [prosome, macropain] subunit β type 2) |
Nucleus, cytoplasm, proteasome |
Ubiquitin-dependent protein degradation. |
| |
Vars (Valine-tRNA synthetase) |
Nucleus |
Valine-tRNA aminoacylation. |
| |
Trap1 (TNF receptor-associated protein 1) |
Cytoplasm, mitochondria |
ATP binding; adaptation to oxidative stress; chaperone activity; protein folding. |
| Signaling |
Calr (Calreticulin) |
Cytoplasm
|
Ca2+ binding; regulator of transcription; regulator of apoptosis. |
| |
Rpsa (Ribosomal protein SA) |
Cellsurface,cytoplasm,nucleoli ribosome |
Translational elongation; cell adhesion; structural constituent of ribosome; receptor activity; ribosome binding. |
| |
Gap43* (Growth associated Protein 43) |
Plasma membrane, synaptosomes |
Calmodulin binding; activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; nervous system development; glial cell differentiation; axon choice point recognition; growth cone guidance; actin dynamics. |
| |
Nudt3 (Nudix [nucleoside diphosphate Linked moiety X]-type motif 3) |
Cytoplasm |
diphosphoinositol-polyphosphate diphosphatase activity; cell-cell signaling; turnover of inositol pyrophosphates. |
| |
Oas1 (2'-5' oligoadenylate synthetase
1H) |
|
anti-viral action of interferon. |
| Cytoskeleton |
Basp1 (Brain abundant, membrane attached signal protein 1) |
Plasma Membrane |
Calmodulin binding; component of brain lipid raft; neuron-specific regulates neurite outgrowth. |
| |
Map2** (Microtubule-associated protein 2) |
Cytoskeleton, cytoplasm |
Negative regulation of microtubule depolymerization; calmodulin binding;
structural molecule. |
| |
Cnp
(2',3'-Cyclic nucleotide 3' phosphodiesterase) |
Cytoplasm |
Phosphodiesterase activity; microtubule cytoskeleton organization; synaptic transmission; axonogenesis; RNA metabolism. |
| |
Efemp2 |
Basement membrane, Extracellular space |
Extracellular matrix structural constituent; calcium ion binding; protein binding; transmembrane receptor activity. |
| Transport |
Ensa
(Endosulfine α)
|
Cytoplasm |
Transport; response to nutrient; receptor binding; ion channel inhibitor activity.
|
Note: *Gap-43 is localized in the plasma membrane and is also a component of the cytoskeletal structure and synapse.