Modified values of IL-1Ra for rat Number of residues in favored region 150 (85.2%) Number of residues in allowed region 17 (9.7%) Number of residues in outlier region 9 (5.1%)

Table 2: Protein structure refinement. The residual values of IL-1Ra in rat were refined by using Chiron protein minimization server (http://chiron.dokhlab.org).