Figure 1: Hemodynamic and inflammatory parameters during endotoxemia and endotoxin tolerance. Hemodynamic and inflammatory parameters of 5 healthy volunteers during 5 consecutive days of 2 ng/kg LPS administrations, to induce a LPS tolerant state. During the first and last day, an arterial cannula registered mean arterial pressure (MAP) and heart rate, continuously. On day 3, this was monitored non-invasively every half hour. Temperature levels were obtained every half hour by use of a tympanic thermometer. C-reactive protein levels were measured once a day before LPS administration, and circulating cytokines were measured every hour on day 1 and 5, and before LPS administration on day 3. The response to LPS administration, with regard to above mentioned parameters were tested for significance by use of ANOVA for repeated measures. Data are expressed as mean ± SEM, whereas the data concerning cytokine levels are expressed in median with interquartile range. “np” indicates ‘not performed’ and * indicates p<0.05.