| |
Day 1 |
Day 3 |
Day 5 |
| Heart rate (/min) |
| |
baseline |
61 ± 2 |
66 ± 3 |
57 ± 2 |
| |
peak level |
97 ± 3* |
86 ± 9 |
78 ± 2 |
| MAP (mmHg) |
| |
baseline |
98 ± 3 |
87 ± 2 |
97 ± 3 |
| |
peak level |
83 ± 4* |
86 ± 4 |
86 ± 2 |
| Temperature (°C) |
| |
baseline |
36.2 ± 0.2 |
35.9 ± 0.2 |
36.1 ± 0.1 |
| |
peak level |
37.6 ± 0.1* |
36.7 ± 0.2 |
36.6 ± 0.1 |
| C-reactive protein (mg/mL) |
| |
baseline |
<5 ± 0 |
30 ± 3 |
24 ± 2 |
| |
after 24 hours |
26 ± 2* |
27 ± 2 |
|
| TNFα (pg/mL) |
| |
baseline |
8 |
8 |
8 |
| |
peak level |
484[366-1124]* |
np |
13[8-14] |
| IL-6 (pg/mL) |
| |
baseline |
8 |
8 |
8 |
| |
peak level |
2153[1674-2236]* |
np |
118[57-222] |
| IL-10 (pg/mL) |
| |
baseline |
8 |
8 |
8 |
| |
peak level |
186[155-265]* |
np |
26[18-34] |
|
