Number of proteins with 2-fold or more change   CL, Up-reg CL, Down-reg SP, Up-reg SP, Down-reg D11 65 38 40 19 D15 68 22 7 18 Total 133 60 47 37 Grand Total       277

Table 3A: A: Number of proteins being modulated (two-fold or higher) in one or both sets of bioreactors on D11 and/or D15. Green: Up-regulated and Red: Down-regulated. Both, intracellular (CL) and secreted (SP) were monitored. B: List of intra-cellular and secreted proteins that were consistently and reproducibly up-regulated or down-regulated (two-fold or higher) in both D11 and D15 samples. C: List of protein families that were consistently and reproducibly modulated in D11 and D15 samples. Different members of these protein families were up-regulated or down-regulated in D11 and D15 samples.