| COX-1 |
COX-2 |
| Site 1 |
Site 2 |
Site 3 |
Site 1 |
Site 2 |
Site 3 |
| ASN 36 |
TYR 150 |
VAL 118 |
ASN 19 |
TYR 134 |
ALA 185 |
| CYS 38 |
ALA 201 |
ARG 122 |
CYS 22 |
THR 192 |
PHE 186 |
| CYS 39 |
PHE 202 |
TYR 350 |
SER 23 |
HIS 193 |
ALA 188 |
| TYR 41 |
ALA 204 |
VAL 351 |
ASN 24 |
PHE 196 |
GLN 189 |
| PRO 42 |
GLN 205 |
LEU 354 |
PRO 25 |
LYS 197 |
THR 192 |
| CYS 43 |
THR 208 |
SER 355 |
CYS 26 |
THR 198 |
HIS 193 |
| GLN 44 |
HIS 209 |
TYR 357 |
GLN 27 |
ASP 199 |
PHE 196 |
| ASN 45 |
PHE 212 |
LEU 361 |
ASN 28 |
HIS 200 |
ASN 368 |
| GLN 46 |
LYS 213 |
PHE 383 |
ARG 29 |
LYS 201 |
TYR 371 |
| GLY 47 |
THR 214 |
LEU 386 |
GLY 30 |
ARG 208 |
HIS 372 |
| VAL 48 |
LEU 296 |
TYR 387 |
GLU 31 |
ASN 217 |
TRP 373 |
| CYS 49 |
TYR 350 |
TRP 389 |
CYS 32 |
HIS 218 |
HIS 374 |
| VAL 50 |
ASN 384 |
PHE 520 |
MET 33 |
GLY 221 |
LEU 377 |
| ARG 63 |
TYR 387 |
MET 524 |
SER 34 |
GLU 222 |
|
| THR 64 |
HIS 388 |
ILE 525 |
ASP 111 |
THR 223 |
|
| TYR 66 |
TRP 389 |
GLY 528 |
THR 115 |
ARG 226 |
|
| ARG 81 |
HIS 390 |
ALA 529 |
TYR 116 |
GLY 274 |
|
| LEU 125 |
LEU 392 |
SER 532 |
GLY 121 |
GLN 275 |
|
| PRO 127 |
MET 393 |
LEU 533 |
TYR 122 |
GLU 276 |
|
| THR 131 |
PHE 397 |
|
LYS 123 |
VAL 277 |
|
| TYR 132 |
TYR 406 |
|
ALA 137 |
ASN 368 |
|
| ASP 137 |
PHE 409 |
|
LEU 138 |
HIS 372 |
|
| TYR 138 |
LEU 410 |
|
PRO 140 |
|
|
| ILE 139 |
VAL 446 |
|
VAL 141 |
|
|
| ILE 153 |
|
|
ALA 142 |
|
|
| LEU 154 |
|
|
CYS 145 |
|
|
| PRO 155 |
|
|
MET 149 |
|
|
| SER 156 |
|
|
GLY 150 |
|
|
| VAL 157 |
|
|
GLN 447 |
|
|
| PRO 158 |
|
|
GLU 451 |
|
|
| LYS 159 |
|
|
TYR 452 |
|
|
| GLN 463 |
|
|
LYS 454 |
|
|
| GLU 467 |
|
|
ARG 455 |
|
|
| LYS 470 |
|
|
SER 457 |
|
|
| ARG 471 |
|
|
|
|
|
| PHE 472 |
|
|
|
|
|
| GLY 473 |
|
|
|
|
|
|
