COX-1 COX-2 Residue Atom Salicin Distance Å Residue Atom Salicin Distance Å ALA 204 CB C10 3.45 ALA 188 CB H3 3.17 GLN 205 OE1 O1 3.67 GLN 189 CB H3 3.74 THR 208 OG1 H3 3.87 THR 192 OG1 H2 2.12 HIS 209 NE2 H1 3.60 HIS 193 CE1 O6 3.79 TYR 387 CD1 C11 3.90 PHE 196 CD2 H4 3.67 TRP 389 CB C8 3.75 ASN 368 ND2 H4 3.89 HIS 390 CD2 H4 3.73 TYR 371 CB H2 3.85 LEU 392 CD1 C13 3.16 HIS 372 O6 NE2 3.49 MET 393 CE C12 3.37 HIS 374 CD2 C7 3.38         LEU 377 CD1 C13 3.68

Table 4: Hydrogen bonds along with their distances between the salicin inhibitor and active site residues of COX proteins as deciphered using Docking server.