DBC1 Interactions Type of Study Effect of DBC1 Reference Functional Relevance Demonstrated AR Targeted Activator [26] BRCA1 Targeted Inhibitor [35] COUP-TF1 Targeted Activator [31] ERα Targeted Activator [28,29] ERβ Targeted Inhibitor [27] HDAC3 Targeted Inhibitor [22] MYC Targeted Activator [59] RARα Targeted Activator [30] Rev-erbα Targeted Activator [33] RNA polII Targeted Activator [44,60] SIRT1 Targeted Inhibitor [19,20] SUV39H1 Targeted Inhibitor [23] Function Unknown ACTR3B High Throughput* Unknown [61] AIMP1 High Throughput* Unknown [62] AIMP2 High Throughput* Unknown [62] ASH2L Targeted NIF-1 Complex [30] BAG2 High Throughput Unknown [63] C11ORF30/EMSY Targeted NIF-1 Complex [30] CCNA1 High Throughput* Unknown [61] CDK7 High Throughput* Unknown [64] CDK9 High Throughput* Unknown [62,64] CEP170 High Throughput* Unknown [65] CIAO1 High Throughput* Unknown [61] CNOT1 High Throughput* Unknown [62] COPS5 High Throughput* Unknown [66] CUL3 High Throughput* Unknown [66] DCTN3 High Throughput* Unknown [62] E1F2S3 High Throughput* Unknown [62] EEF1A1 High Throughput* Unknown [67] EEF1E1 High Throughput* Unknown [62] FN1 High Throughput* Unknown [68] GBF1 High Throughput* Unknown [62] GSTK1 High Throughput* Unknown [61] HDAC5 Targeted Unknown [8] HNRNPA1 High Throughput Unknown [62] HSPA8 High Throughput Unknown [63] HTRA2 Targeted Unknown [69] IQGAP1 High Throughput Unknown [62] ITGA4 Targeted Unknown [70] KBTBD7 High Throughput* Unknown [71] KIAA0101 High Throughput* Unknown [72] MAGEA6 High Throughput* Unknown [61] MAGED1 High Throughput* Unknown [61] MEPCE High Throughput* Unknown [64] METTL21B Targeted Unknown [73] METTL23 Targeted Unknown [73] NCAPD2 High Throughput* Unknown [62] NCAPG High Throughput* Unknown [62] NEK6 High Throughput* Unknown [61] pADPr Targeted Unknown [41] PLEC High Throughput* Unknown [62] PNMA1 Targeted Unknown [74] PRMT5 High Throughput Unknown [63] QARS High Throughput* Unknown [62] RAD21 Targeted Unknown [75] RARS High Throughput* Unknown [62] RbBP5 Targeted NIF-1 Complex [30] RPL27A High Throughput* Unknown [62] RUVBL2 High Throughput* Unknown [64] SIRT7 High Throughput* Unknown [2] SF3A2 Targeted Unknown [76] SMC2 High Throughput* Unknown [62] SMC4 High Throughput* Unknown [62] TH1L High Throughput* Unknown [61] WRAP73 High Throughput* Unknown [61]

Table 1: DBC1 protein interactions. Validated and putative DBC1 interactions identified via targeted or high-throughput mass spectrometry-based studies are indicated. *refers to large-scale mass spectrometry-based interactome studies.