Protein

Ankyrin

Domain

Ion channels:

 

 

Rh antigen

R

 

IP3R

B

MBD

CaV1.3

B

 

Kir6.2

B

MBD

NaV1.X

G

MBD

KV7

G

 

KV3

G

 

CNG-b

G

 

Ion transporters:

 

 

Anion exchanger (AE1, 2, 3)

R

MBD

NCX

R, B

MBD

NKA

R, B, G

MBD

Ammonium transporter

R, G

 

Cell adhesion molecules:

 

 

CD44

R

MBD

L1-CAM family

R, B, G

MBD

E-cadherin

G

 

b-dystroglycan

G

 

Cytoskeletal/structure:

 

 

b-spectrin

R, B, G

SBD

Obscurin

R, B, G

CTD

Dystrophin

B, G

 

Filamin C

G

CTD

Plakophilin-2

G

 

Plectin

G

CTD

Intracellular transport:

 

 

Clathrin

R

MBD

Tubulin

R, B

MBD

EHD1-4

B

MBD

Dynactin-4

B

SBD

EB1/3

G

 

Other:

 

 

PP2A

B

SBD

Hdj1/Hsp40

B

CTD

Fas

G

DD

Tiam-1

R, G

MBD

Sigma receptor

B

 

Table 1: Proteins that interact with ankyrins (R, B, or G) are grouped according to their general function. Sites of interaction on ankyrin are listed (MBD: membranebinding domain, SBD: spectrin-binding domain, DD: death domain, CTD: C-terminal domain).