Table 2

	fmol / µg membrane protein (%CV)a,b
Donor (Gender, Age, Ethnicity)	OATP1B1	OATP1B3	OATP2B1
Male, 66, Unknown	14.9 ± 0.4 (7.8)	6.6 ± 0.2 (7.9)	3.6 ± 0.2 (13.7)
Male, 45, Asian	13.7 ± 0.4 (9.0)	11.8 ± 0.2 (4.9)	4.6 ± 0.2 (12.1)
Male, 50, Asian	3.1 ± 0.1 (12.0)	2.8 ± 0.1 (12.0)	1.2 ± 0.1 (12.0)
Female, 65, Unknownc	10.6 ± 0.3 (4.6)	2.4 ± 0.1 (3.8)	2.0 ± 0.1 (5.3)

^aMembrane fractions were initially denatured in 25 mM ABC containing 10%
DOC prior to alkylation, dilution, and digestion.
^bData represent the mean ± S.E.M. and coefficient of variation (CV%) for
three transitions measured for each peptide by LC-MS/MS for 44 hr digestions
processed in triplicate.
^cFinal quantification values for the fourth liver tissue are representative of the
mean of three transitions measured for each peptide for a single sample.

Table 2: Quantification of OATP1B1 (surrogate-1), OATP1B3 (surrogate-2), and OATP2B1 (surrogate-1) peptides in human liver membrane fractions.