Figure 1: Heat map representation of genes in Human lung epithelial (A549) cells infected with A) Low pathogenic reverse genetics modified vaccine strain of H5N1 B) Highly pathogenic avian influenza(HPAI)-H5N1 C) seasonal influenza H1N1 and D) pandemic influenza H1N1(2009). Cells were analyzed at 4 different time point post-infection (4h, 8h, 16h and 24h). Expression of genes with fold change >+/- 1.5 and p < 0.05 were considered as differentially expressed. Red indicates upregulation whereas green indicates down-regulation. Data presented are averaged gene expression changes for 2 different replicates. There is a clear difference in the expression pattern of host genes in cells infected with influenza A viruses of different pathogenecity.