Combo ID Amino acid combination Chronic Occult Two-sided p-value 4 R138+N139 90.36% 70.83% 0.0390 6 H126R+R138 16.87% 0 0.0362 6 H126Q+R138 1.20% 16.67% 0.0087 16 M129+N131 80.72% 62.5% 0.0976 16 M129+N131K 0 12.5% 0.0102

Table 11: Detailed interactions for H4 positions in genotype-D.