| Review Article |
Open Access |
|
| Pharmaceutical Technologies for Enhancing Oral
Bioavailability of Poorly Soluble Drugs |
| Yellela S.R. Krishnaiah* |
| College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA |
| *Corresponding author: |
Yellela S.R. Krishnaiah, PhD, Associate Professor
of Pharmaceutics,
Department of Pharmaceutical Sciences, College of
Pharmacy,
Nova Southeastern University, 3200,
South University Drive, Fort
Lauderdale,
FL 33328, USA,
Tel: 954-262-1529 (O),
Fax: 954-262-2278. |
|
| |
| Received January 29, 2009; Accepted March 30, 2010; Published
March 30, 2010 |
| |
| Citation: Krishnaiah YSR (2010) Pharmaceutical Technologies for Enhancing
Oral Bioavailability of Poorly Soluble Drugs. J Bioequiv Availab 2: 028-036. doi: 10.4172/jbb.1000027 |
| |
| Copyright: © 2010 Krishnaiah YSR. This is an open-access article distributed
under the terms of the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited. |
| |
| Abstract |
| The oral bioavailability of BCS (biopharmaceutics classification
system) class II drugs with poor solubility and
reasonable permeability is limited by the drug dissolution
step from drug products. Though prodrug approach is an
exciting way of improving the oral bioavailability, it requires
extensive studies to establish the safety profile of
prodrugs in humans. In view of the increasing market share
of oral drug products, a variety of technologies are developed
to enhance the oral bioavailability of poorly soluble
drugs using the excipients with approved or GRAS (generally
regarded as safe) status. The present review describes
the main technologies such as micronization, nanosizing,
crystal engineering, solid dispersions, cyclodextrins, solid
lipid nanoparticles and other colloidal drug delivery systems
with a few relevant research reports. |
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