| Research Article |
Open Access |
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| Comparative Bioavailability of Two Brands of Ofloxacin in
Healthy Human Volunteers |
| Rajani Shakya1*, Manila Hada1, Panna Thapa1, R. N. Saha2 |
| 1Department of Pharmacy, Kathmandu University, Nepal |
| 2BITS, Pilani, Rajasthan, India |
| *Corresponding author: |
Dr. Rajani Shakya,
Department of Pharmacy,
Kathmandu University,
Nepal,
E-mail: rajani.shakya@gmail.com |
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| Citation: Shakya R, Hada M, Thapa P, Saha RN (2010) Comparative Bioavailability of Two Brands of Ofloxacin in Healthy Human Volunteers. J Bioequiv Availab 2: 055-058. doi: 10.4172/jbb.1000031 |
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| Copyright: © 2010 Shakya R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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| Abstract |
| The relative bioavailability and pharmacokinetics of a locally manufactured (Oquin) and reference (Zanocin) formulations of ofloxacin were compared. Each volunteer received a single dose of 200 mg ofloxacin tablet, test or reference with a 7 days washout period. Multiple blood samples were collected and plasma concentrations of ofloxacin were analyzed by high performance liquid chromatography technique. |
Following oral administration of both formulations, there was rapid and extensive oral absorption from gastrointestinal
tract achieving maximum serum concentration within 2 hrs. The concentration-time profile generated by the two products
was found to be superimposable. Peak plasma concentration (Cmax), area under the serum concentration-time curve
(AUC0-24), area under the serum concentration-time curve extrapolated to infinity (AUC0-∞) and serum elimination halflife
(t½) were 1.98 ± 0.213 and 1.82 ± 0.194 μg/ml, 13.19 ± 1.45 and 12.56 ± 0.965 μg.hr/ml, 13.86 ± 1.49 and 13.14 ±
0.959μg.hr/ml, 5.55 ± 1.37 and 5.55 ± 0.715 hr for Oquin and Zanocin, respectively. |
The result indicates that these two formulations have similar rate as well as extent of absorption. Hence these two products can be said to have comparable bioavailability. |
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