Parameters   Laninamivir octanoate dose       20 mg (N=8) 40 mg (N=8) laninamivir AUC0-tz ng・h/mL 440 (82) 1018 (242) Octanoate AUC0-inf ng・h/mL 446 (83) 1023 (241)   Cmax ng/mL 145 (40) 336 (112)   tmax h 0.25 (0.25-0.25) 0.25 (0.25-0.25)   t1/2 h 1.79 (0.11) 2.70 (0.40)   CL/F mL/min 774 (174) 694 (207)   Vz/F L 121 (27) 160 (50)   Xu0-144h % 4.7 (1.1) 5.5 (1.5)   CLR mL/min 34.3 (5.1) 35.9 (6.1) laninamivir AUC0-tz ng・h/mL 558 (96) 1080 (156)   AUC0-inf ng・h/mL 693 (116) 1379 (210)   Cmax ng/mL 19.0 (3.1) 38.3 (9.8)   tmax h 4.0 (3.0-6.0) 4.0 (3.0-6.0)   t1/2 h 66.6 (9.1) 74.4 (19.3)   Xu0-144h % 19.2 (4.0) 23.3 (2.6)   CLR mL/min 84.9 (18.5) 106.9 (18.1) Values are arithmetric mean (SD), except for tmax, which is expressed as median (range) AUC0-tz, area under the concentration-time curve up to the time of the last mesurable concentration data AUC0-inf, AUC values extrapolated to infinity; Cmax, maximum concentration; tmax, time to Cmax; t1/2, half-life CL/F, apparent total body clearance; Vz/F, apparent volume of distribution Xu0-144h, the cumulative percentage of dose excreted in urine up to 144 hours; CLR, renal clearance

Table 2: Pharmacokinetic parameters of laninamivir octanoate (LO) and laninamivir after a single inhaled administration of LO using a new easy-to-use inhaler in healthy human volunteers.