Baseline demographic and prognostic criteria (subgroup analysis with simultaneous ISC-Qu) initial sample size 318 (106 vs. 212) Value (test) ISC-Qu group % or mean (± SD) Value control group % or mean (± SD) Valid N test / control group p-values (Chi-Square, exact Fisher’s, or Mann-Whitney-test)
Age at onset of aftercare; mean,(SD) years: 53.7 (10.9) 58.3 (9.5) 106 / 212 0.001
Body weight; mean, (SD) kg: 73.9 (9.9) 76.8 (13.7) 101 / 206 0.147
Body height; mean, (SD) cm: 177.4 (7.3) 171.5 (8.6) 105 / 208 <0.001
Gender males / females % 76.4 / 23.6 56.6 / 43.4 106 / 212 0.001
Tumor stage “high-risk” (T3 / T4) % 67.0 72.0 106 / 211 0.364
Tumor stage node positive (N1/2) % 78.3 41.7 106 / 211 <0.001
Tumor stage grading (G3/G4) (highly malignant) % 42.9 15.2 105 / 211 <0.001
Tumor stage UICC III (advanced) % 78.3 41.7 106 / 211 <0.001
Tumor localization colon or rectal, % 55.7 / 44.3 60.7 / 39.3 106 / 211 0.400
Tumor postsurgical completely removed (CR, NED) % 96.2 94.0 106 / 200 0.591
Symptoms present at baseline % 94.3 74.5 106 / 212 <0.001
Other concurrent diseases (multi-morbidity) present %: 43.8 64.1 105 / 206 0.001
1st surgery to ONC therapy begin time; mean, (SD), months 1.0 (6.8) 3.4 (7.8) 106 / 211 <0.001
Aftercare / follow-up duration up to the last information; mean (SD), and median (range), months 59.1 (25.6) 59 (11-155)) 49.9 (25.1) 43 (2-144) 106 / 210 <0.001
SD (standard deviation)
Table 1: Demographic data, tumor staging and co-morbidity.