Therapeutic approach Metabolic target Agent
Inhibition of glycolysis Hexokinase
Hexokinase VDAC complex
Lactate dehydrogenase
Pyruvate dehydrogenase
kinase (PDK)
Phosphofructokinase
Pyruvate kinase (PK)
2-Deoxyglycose,
3-bromopyruvate, lonidamine.
Methyl jasmonate
Oxamate α-cyano-4-hydroxy
cinnamic acid
Dichloroacetate
(3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
CAP-232/TLN-232
Glutamine metabolism

Glutamine (analogs)
Glutamine

6-Diazo-5-oxo-L-norleucine,
azaserine
L-Asparginine, Phenylbutyrate
PI3K/AKT/mTOR PI3K
mTOR
AKT
LY294002, Wortmannin,
GDC-0941, PX-866, CAL-101,
BEZ235 and XL765.
Temsirolimus (CCI779) and
Everolimus (RAD001)
Perifosine, PIAs Triciribine (API-2)
Table 1: Therapeutic strategies to target metabolic enzymes and relevant agents.