OR

SD + PD

p

Age (years)
 Means ± standard deviation
Gender (M/F)

 

58.65 ± 8.53

 

56.27 ± 10.75

 

0.426

 Male

16 (34.0%)

31 (66.0%)

0.412

 Female

1 (14.3%)

6 (85.7%)

 

Etiology
HBV + HCV
Alcohol + Idiopathic

14 (31.8%)
3 (30.0%)

30 (68.2%)
7 (70.0%)

1.000

Type of tumor

Single + Massive
Diffuse + Multi-nodular

8 (25.0%)
9 (40.9%)

24 (75.0%)
13 (59.1%)

0.246

PVTT

Yes
No

9 (22.5%)
8 (57.1%)

31 (77.5%)
6 (42.9%)

0.023

Grade of PVTT

Vp2
Vp3
Vp4

1 (16.7%)
2 (12.5%)
6 (33.3%)

5 (83.3%)
14 (87.5%)
12 (66.7%)

0.405

Child-Pugh Class

A
B + C

10 (30.3%)
7 (33.3%)

23 (69.7%)
14 (66.7%)

1.000

Albumin (g/dL)
≥ 3.5
< 3.5
5 (23.8%)
12 (36.4%)
16 (76.2%)
21 (63.6%)
0.383

Bilirubin (mg/dL)

≤ 1.2
〉 1.2

8 (34.8%)
9 (29.0%)

15 (65.2%)
22 (71.0%)

0.769

PT (INR)

≤ 1
〉 1

1 (12.5%)
16 (34.8%)

7 (87.5%)
30 (65.2%)

0.260

ALT (U/I)

〉 40
≤ 40

7 (26.9%)
10 (35.7%)

19 (73.1%)
18 (64.3%)

0.565

AFP (ng/mL)

≥ 200
〈 200

7 (21.2%)
10 (47.6%)

26 (78.8%)
11 (52.4%)

0.070

Ascites

Yes
No

3 (25.0%)
14 (33.3%)

9 (75.0%)
28 (66.7%)

0.732
Previous treatment
Yes
No
10 (37.0%)
7 (25.9%)
17 (63.0%)
20 (74.1%)
0.559
OR: Objective response; SD: Stable disease; PD: Progressive; HBV: Hepatitis B Virus; HCV: Hepatitis C Virus; PVTT: Portal Vein Tumor Thrombosis; Vp1: Invasion (or tumor thrombus in) distal to the second order branches of the portalvein, but not of the second order branches; Vp2: Invasion of (or tumor thrombus in) second order branches of the portal vein; Vp3: Invasionof (or tumor thrombus in) first order branches of the portal vein; Vp4: Invasion of (or tumor thrombus in) the main trunk of the portal veinand/or contra-lateral portal vein branch to the primarily involved lobe; PT: Prothrombin Time; INR: International Normalized Ratio; ALT: Alanine Transaminase: AFP: Alpha-fetoprotein; HAIC: Hepatic Arterial Infusion Chemotherapy; 5-FU: Fluorouracil
Table 2: Effect of Pre-treatment Variables on the Therapeutic Effect of HAIC in Patients with Advanced HCC according to the Results of Univariate Analysis.