| Item | 
        Description | 
         
      
        | Complete response (CR) | 
        A pain    score of 0 at treated site with no concomitant increase in analgesic intake    (stable or reducing analgesics in daily oral morphine equivalent [OMED])  | 
         
      
        | Partial response (PR) | 
        Pain    reduction of 2 or more at the treated site on a scale of 0 to 10 scale    without analgesic increase, or Analgesic reduction of 25% or more from    baseline without an increase in pain.  | 
         
      
        | Pain progression   | 
        Increase    in pain score of 2 or more above baseline at the treated site with stable    OMED, or An increase of 25% or more in OMED compared with baseline with the    pain score stable or 1 point above baseline.  | 
         
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