Application Mediator Conjugation technique Activation of enzymes Antibody NHS-Maleimide conjugation Activation of enzymes Antibody 2-Iminothiolane conjugation Activation of enzymes Antibody Glutaraldehyde mediated conjugation Attaching thiol reactive groups Dendrimers NHS-PEG-Maleimide conjugation Coupling glycoproteins Dendrimers Reductive amination Iodine incorporation Small molecules Iodination using Chloramine-T Coupling to hydrazide particles Nanoparticles Carbodiimide reaction Antigen /hapten conjugation Liposomes Simple mixing with specific buffers Antibody-liposome conjugate Liposome Sulfhdryl residue coupling or reductive amination Liposome-mAb conjugation Liposome NHS ester of palmitic acid

Table 3: Specific reactions used for the modification of small molecules, antibody, dendrimeror nanoparticlesfor targeted drug delivery.