Drug FGFR1 FGFR2 FGFR3 FGFR4 VEGFR2 Reference IC50 (nM) Nintedanib 47 69 63 37 122 108 451 610 21 [29] [82] Brivanib 165 15 202 32 530 52 2023 >1000 4.2 [29] [83] Dovitinib 16 13 50 21 53 18 341 470 5.4 [29] [83] Cediranib 5 26 33 36 697 <1 [29] [84] Ponatinib 2 2 18 8 1.5 [29] Sunitinib 437 852 314   34 [81] Sorafenib 64 825 1019   28 [81] Pazopanib 80 350 138   15 [81] Axitinib 231       0.2 [85] LY2874455 2.8 2.6 6.4 6 7 [28] AZD4547 0.2 2.5 1.8 165   [86] BGJ398 0.9 1.4 1 60 180 [27] Regorafenib 202       4.2† [87] XL228 8 2 3     [88] *Data may vary between different references for the same compound due to differences in assay methodology. References that compare potency across various agents are preferentially cited when available. † murine VEGFR2

Table 1: Comparison of FGFR/VEGFR kinase inhibition profile of various FGFR inhibitors*.