| Drug |
p110α |
p110β |
p110δ |
p110γ |
mTOR |
Reference |
| GDC-0941 |
3 |
33 |
3 |
75 |
|
[89,90] |
| PX-866 |
6 |
>300 uM |
3 |
9 |
|
[91] |
| BKM120 |
52 |
166 |
116 |
262 |
2866 |
[56] |
| XL147 |
39 |
383 |
36 |
23 |
>15000 |
[92] |
| ZSTK474 |
16 |
44 |
5 |
49 |
|
[93] |
| CAL-101 |
>100 uM |
1820 uM |
70 |
1240 |
|
[94] |
| CH5132799 |
14 |
120 |
500 |
36 |
1600 |
[62] |
| PF-04691502 |
1.8 |
2.1 |
1.6 |
1.9 |
16 |
[64] |
|
PF- 05212384 |
0.4 |
6 |
8 |
6 |
1 |
[65] |
| GSK2126458 |
0.019 |
0.13 |
0.024 |
0.06 |
0.18 |
[95] |
| XL765 |
39 |
113 |
43 |
8 |
157 |
[96] |
| BEZ235 |
4 |
75 |
7 |
5 |
21 |
[97] |
| SF1126 |
356 |
736 |
3225 |
1774 |
1060 |
[98] |
| GDC-0980 |
5 |
27 |
7 |
14 |
17 |
[99] |
|