Authors Year   Tracer Sensitivity/specificity PPV/NPV Number of patients enrolled Ahlstrom et al. [8] 1996 18F-FDG 0.78 (sensitivity) NA 23 Kosuda et al. [7] 1997 18F-FDG 0.67 (sensitivity) NA 12 Bachor et al. [9] 1999 18F-FDG 0.67/0.86 NA 64 Drieskens et al. [11] 2005 18F-FDG 0.60/0.88 NA 55 Liu et al. [13] 2006 18F-FDG 0.77/0.97 NA 46 Anjos et al. [4] 2007 18F-FDG 0.54/1 NA 11 Jadvar et al. [16] 2008 18F-FDG 1/0.54 NA 35 Kibel et al. [14] 2009 18F-FDG 0.70/0.94 0.78/0.91 43 Apolo et al. [15] 2010 18F-FDG 0.87/0.88 NA 47 Harkirat et al. [5] 2010 18F-FDG 0.87/1 1/0.78 22 Lodde et al. [6] 2010 18F-FDG 0.85/0.25 (bladder) 0.75/1 (LN based) NA 44 Swinnen et. al. [12] 2010 18F-FDG 0.46/0.97 NA 51 Jensen et al. [10] 2011 18F-FDG 0.33/0.93 0.50/0.88 18 Golan et al. [21] 2011 18F-FDG 11C-choline   18F-FDG: 0.91 (PPV, bladder) 0.88 (PPV, MET) 11C-choline: 0.85 (PPV, bladder) 0.79 (PPV, MET) 20 Ahlstrom et al. [8] 1996 18F-FDG 11C-methionine 0.78 (sensitivity, 11C -methionine) NA 23 (only 2 with also 18F-FDG) De Jong et al. [25] 2002 11C-choline 0.91 (sensitivity) NA 11 Gofrit et al. [24] 2006 11C-choline 1 (sensitivity) NA 18 Picchio et al. [23] 2006 11C-choline 0.96 (sensitvity, bladder) 0.62 (sensitivity, LN) NA 27 Maurer et al. [22] 2012 11C-choline 0.58/0.66 0.39/0.81 44 Letocha et al. [27] 1994 11C-methionine NA NA 44 Schoder et al. [28] 2012 11C-acetate 1/0.88 NA 17

Table 1: PET/CT studies included in the review.