Paper Data Source Time Period Total Pop. Group Total Pop. Pop. Sub-Group Pop. Number Mean Age (yrs) Staging p-value Treatment Survival/Mortality
Busby et al.5 MD Anderson Cancer Center 1990-2004 Non-urothelial UUT Tumors 16 Squamous Cell Carcinoma UUT Non-Squamous Cell Carcinoma of UUT 12 4 --- --- Squamous Cell: T2 (1 case) T3 (7 cases) T4 (4 cases) All were N1 or Nx and M0 or Mx. All were Grade 2-3. --- Squamous Cell: 12/12 underwent surgical resection 1/12 underwent neoadjuvant chemo 11/12 underwent adjuvant or salvage chemo Squamous Cell: 7/12 passed from disease. Median survival of 11.3 mos. One year survival: 50% All Patients (n=16): 9/16 passed from disease. Median survival of 11.3 mos. One year survival: 47%
Holmang et al.16 Swedish Cancer Registry 1971-1998 Malignant ureteral or renal pelvic tumor 943 Squamous Cell Carcinoma (SCC) vs. Urothelial Carcinoma (UC) 65 743 68.9 years 69.3 years SCC UC pTa 0% 47% pT1 2% 10% pT2 2% 5% pT3 65% 31% pT4 29% 6% pTx 3% 2% ---- <0.01 0.02 <0.01 <0.01 0.37 Nephrouretctomy, Nephrectomy, or Resection: 89% Post-op chemo 12% Nephrouretctomy, Nephrectomy, or Resection 84% Post-op chemo 9% SCC UA p-value Alive 12% 14% 1 Died of Dis 19% 19% ----- Died from Tumor 69% 67% 0.86 Months of post-op survival: SCC: Mean 25 months UC: Mean 40 months p-value 0.07
Li et al.9 University of Hong Kong; Queen Mary Hospital 1970-1985 Malignant tumors of the kidney 144 Squamous Cell Carcinoma of the Renal Pelvis 11 60 years All had local infiltration and regional lymph node involvement. --- Nephrectomy or nephrouretectomy: 7 Of surgical intervent: Adjuvant radiation: 2 Adjuvant chemo and radiation: 1 Of patients without further post-surgical interventions: Mean one month survival (2 weeks – 2 mos) Of those with post-surgical chemo/chemoradiation: Mean 12.5 months (1 week-6 yrs) 10/11 died from recurrent malign
Korkes et al.15 School Med Sciences, Brazil 1994-2004 All UUT Tumors 33 Urothelial Tumors Squamous Cell Carcinoma 93.9% 6.1% 65 ± 16 years Squamous Cell: All cases had pT3 pathological stage except one with pT4. --- All Patients: Nephroureter-ectomy 65%; radical cystectomy 6%; distal ureterectomy only 16%; only nephrectomy 13%. All Patients (No SCC Subgroup): 10% Alive 30% Died to Other Causes 5% Died from Surgical Complicat. 55% Died from Malignancy
Kinn18 Karolinska Hospital, Sweden 1970-1972 Squamous and transitional cell carcinoma 42 Squamous Cell Carcinoma Transitional Cell Carcinoma 15 27 Median: 69 years Median: 58 years Squamous Cell Differentiation: Well Diff: 5 Mod Diff: 6 Poor Diff: 4 --- Nephrectouretecomy 21/27 TCC; 8/15 SCC Nephrectomy: 3/27 TCC; 4/15 SCC Squamous Cell Carcinoma: 1/15 had five year survival Death 1 yr s/p nephrectomy: 67% Transitional Cell Carcinoma: 10/18 had five year survival Death 1 yr s/p nephrectomy: 22%
Wagle et al.1 Roswell Park Memorial Institute, Buffalo, NY 1942-1966 Renal tumors/ Renal pelvic tumor 334/78 Squamous Cell Carcinoma 12 67 years Squamous Cell: Grade III: 3 Grade IV: 9 --- 1/12 were inoperable and no further therapy 3/12 Nephrouretectomy 3/12 Nephrouretectomy and radiation 3/12 Nephrouretectomy and chemotherapy 1/12 Nephrouretectomy and chemoradiation Squamous Cell Carcinoma: 1 year survival: 33.3 2 and 5 year survival: 8.3 10 year survival: None
Donnelly et al. Medical College of Virginia 1965-1975 Renal pelvic carcinomas 22 Squamous Cell Carcinoma Transitional Cell Carcinoma 9 13 64 years --- --- --- Squamous Cell Carcinoma: 1/9 Alive after three years 1/9 Alive after two years Disease specific mortality 77% TCC: 1/13 at one year 2/13 at two years 1/13 at 4.5 years 1/13 at 7 years. Disease specific mortality 46%
The table above displays selected publications with relevant outcome charactersitics, reviewed for this publication. * Nephrouretctomy, Nephrectomy, or Resection. UTT; upper urinary tract. TCC; transitional cell carcinoma; SCC; squamous cell carcinoma

Table 1: Reports of Squamous Cell Carcinoma of the Upper Urinary Tract in the English Literature.