Authors (ref) Journal Scanner N of patients Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%) Murthy et al. [46] J Nuc Med Laboratory PEM System 16 80 100 100 67 86 Berg et al. [44] Breast J PEM flex 77 93 83 87 91 88 Berg et al. [47] Radiology Naviscan 388 41 79.9 66 - 64.9 Tafra et al. [48] Am J Surg - 44 89 - - - - Rosen et al. [49] Radiology Laboratory PEM System 23 86 67 90 25 83 Levine et al. [50] Ann Surg Oncol Laboratory PEM System 17* 86 91 86 91 89 Eo et al. [45] The Breast PEM flex Solo II; Naviscan 113 95 - - - - *18 lesions

Table 2: Diagnostic accuracies for detection of primary breast cancer according to PEM.