Figure 1


Figure 1: DNA double-strand breaks damage and repair mechanisms. In normal mammalian cells, the classic NHEJ (C-NHEJ) pathway is the major repair pathway, as Homologous Recombination needs the sister chromatid and preferentially takes place in the S/G2 phases. At the DSBs, C-NHEJ proceeds through the recruitment of Ku70/80 and DNA-PK catalytic subunit (cs), XLF, XRCC4 and DNA Ligase IV. Although A-NHEJ is a minor DSB repair pathway, it may take over in specific situations (e.g. when Ku is absent) therefore leading to error-prone repair of DNA-damage.

Figure 1: DNA double-strand breaks damage and repair mechanisms. In normal mammalian cells, the classic NHEJ (C-NHEJ) pathway is the major repair pathway, as Homologous Recombination needs the sister chromatid and preferentially takes place in the S/G2 phases. At the DSBs, C-NHEJ proceeds through the recruitment of Ku70/80 and DNA-PK catalytic subunit (cs), XLF, XRCC4 and DNA Ligase IV. Although A-NHEJ is a minor DSB repair pathway, it may take over in specific situations (e.g. when Ku is absent) therefore leading to error-prone repair of DNA-damage.