Figure 1: Intracellular concentrations of NNRTI in PBMCs treated with nevirapine and efavirenz. Open and closed bars indicate the log intracellular concentrations of nevirapine and efavirenz in PBMCs treated with different concentrations for 48 hrs, respectively. Significant differences were observed when the intracellular concentrations were compared with the same Cmax (P < 0.01). Cmax: the mean peak steady-state levels in human plasma during antiretroviral therapy.