| 
        Univariate analysis  | 
        Multivariate analysis   | 
       
      
        Variates  | 
        HR (95% CI)  | 
        P value  | 
        HR (95% CI)   | 
        P value   | 
       
      
        Age, per year  | 
        1.12 (1.06-1.19)  | 
        <.0001  | 
        1.11(1.05-1.19)  | 
        0.0003*   | 
       
      
        Hypertension (+)  | 
        1.27 (0.35-3.81)  | 
        0.6880  | 
        -  | 
        -  | 
       
      
        DM (+)  | 
        0.95 (0.05-4.80)  | 
        0.9653  | 
        -  | 
        -  | 
       
      
        HBV or HCV infection (+)  | 
        1.29 (0.20-4.74)  | 
        0.1556  | 
        -  | 
        -  | 
       
      
        Smoking (+)  | 
        1.29 (0.45-4.20)  | 
        0.6426  | 
        -  | 
        -  | 
       
      
        CD4 cell count, cells/µL   | 
        0.997 (0.994-1.001)  | 
        0.1390  | 
        -  | 
        -  | 
       
      
        Serum albumin, g/dL  | 
        0.13 (0.06-0.41)  | 
        0.0013  | 
        0.26 (0.06-1.44)  | 
        0.1202  | 
       
      
        eGFR < 60mL/min/1.73 m2 (+)  | 
        2.73 (0.62-8.74)  | 
        0.1637  | 
        -  | 
        -  | 
       
      
        Serum cystatin    C elevation (+)   | 
        8.01 (2.64-23.0)  | 
        0.0006  | 
        3.56 (1.06-11.2)  | 
        0.0408*   | 
       
      
        C-reactive protein, mg/dL  | 
        1.27 (1.05-1.42)  | 
        0.0200  | 
        1.18 (0.96-1.38)  | 
        0.1052  | 
       
     
      The multivariate Cox proportional hazards model was adjusted for age, serum
        albumin, and C-reactive protein, all of which showed significance (P ≤ 0.10) in
        the univariate analysis. Asterisk (*) indicates that the parameter is significantly
        associated with the incidence of the outcome. 
      Abbreviations: DM: diabetes mellitus; HBV: hepatitis B virus; HCV: hepatitis C
        virus; eGFR: estimated glomerular filtration rate         
     
       |