Grade 3-4 toxicities

Number of patients

Percentage of patients

ANC < 1,000 cells/mm3

61

52.58

Diarrhea

5

4.31

Encephalopathy

1

0.86

Diarrhea + ANC < 1,000

3

2.59

Mucositis

1

0.86

Anorexia

3

2.59

Encephalopathy + ANC < 1,000

2

1.72

Total

76

65.51
Table 2: Number and percentage of patients who developed grade 3-4 toxicities after the first or second cycle of 5-FU based regimens chemotherapy.