rs4244285 and rs662 population data was retrieved from the Hap Map #28 Project. African data is composed from individuals of African ancestry in Southwest USA; Luhya in Webuye, Kenya; Maasai in Kinyawa, Kenya; Yoruba in Ibadan, Nigeria. Europe: Utah residents with N & W European ancestry from the CEPH collection; Toscans in Italy. East Asia: Han Chinese in Beijing, China; Chinese in Metropolitan Denver, Colorado; Japanese in Tokyo, Japan. America: Mexican ancestry in Los Angeles, California. rs4986893 and rs1065852 population data was retrieved from the 1000 Genomes Phase I Project: African data is composed from individuals of African ancestry in Southwest USA; Luhya in Webuye, Kenya; Yoruba in Ibadan, Nigeria. Europe: Utah residents with N & W European ancestry from the CEPH collection; Finnish in Finland; British in England and Scotland; Iberian populations in Spain; Toscans in Italy. East Asia: Han Chinese in Beijing, China; Han Chinese South; Japanese in Tokyo, Japan. America: Colombian in Medellín, Colombia; Mexican ancestry in Los Angeles, California [17].

Figure 2: Minor Allele Frequency (MAF) corresponding to genetic polymorphisms on CYP2C19*2, PON1 and CYP2D6 loci in Puerto Ricans and 4 other reference populations. Comparison between Puerto Ricans and other reference populations using a Z-test for proportions is shown. 5% significance level was selected. A graph corresponding to CYP2C19*3 is not shown since we did not found the polymorphism in the samples analyzed.