UGT1A1 is the liver enzyme that conjugates the bilirubin to be eliminated. The insertion of an extra dinucleotide (TA) on the UGT1A1 promoter results in a decreased enzyme activity. Patients with this genetic condition who are treated with ATV will face higher risk of developing severe hiperbilirubinemia, compared to those not showing this specific genetic condition. The graphic shows the percentage of patients on ATV300/r who develop severe hyperbilirrubinemia according to the UGT1A1 genotype.
UGT1A1: uridine diphosphate glucuronosyltransferase 1A1; ATV: atazanavir.
