Figure 4: Main transport proteins involved in elimination of TFV from tubular renal cells. Genetic polymorphisms in transport proteins may influence the elimination of TFV. The more relevant polymorphisms associated with tubular damage are listed on the right side of the figure. TFV: tenofovir; TFV-MP: tenofovir monophosphate; TFV-DP: tenofovir diphosphate; OAT1: organic anion transporter protein-1; OAT3: organic anion transporter protein-3; MRP2: multidrug resistant protein-2; MRP4: multidrug resistant protein-4; MRP7: multidrug resistant protein-7.