Rank “DRUG is metabolized by GENE” “GENE substrate DRUG” 1 “DRUG is metabolized by GENE” “GENE substrate DRUG” 2 “DRUG is metabolised by GENE” “GENE mediated DRUG” 3 “DRUG is metabolized GENE” “GENE catalyzed DRUG” 4 “DRUG metabolism by GENE” “GENE substrates DRUG” 5 “DRUG, a substrate for GENE” “GENE dependent DRUG” 6 “DRUG, which is GENE” “GENE activity (DRUG” 7 “DRUG in relation to GENE” “GENE genotype and DRUG” 8 “DRUG on the activity of GENE” “GENE probe drug DRUG” 9 “DRUG oxidation (GENE” “GENE substrates such as DRUG” 10 “DRUG is substrate for GENE” “GENE activity as DRUG”

Table 1: Top 10 ranked patterns (as determined by the F1-based ranking)using seed patterns “DRUG is metabolized by GENE” and “GENE substrate DRUG”.