Relationship Pattern Pairs (n) Precision Pairs not in PharmGKB (n) Metabolism “DRUG pattern GENE” 76 0.973 14 “GENE pattern DRUG” 124 1.000 28 Target “DRUG pattern GENE” 832 0.961 708 “GENE pattern DRUG” 193 1.000 116

Table 3: Precision of four sets of selected patterns in extracting drug-gene pairs from MEDLINE and the numbers of additional pairs extracted compared to ones in PharmGKB.