Figure 3: Divergences SVD. Row 1 Left: Biplot of carbamazepine drug-induced HSR. Note upper SNP deter-minants of severe disease versus SNPs to the right predisposing for mild disease. Middle: Haplotype network of carbamazepine drug-induced HSR showing CTLA4 dominated-versus ICOS dominated-haplotype and one ‘lynchpin’ SNP in common. Right: ‘This-sample’ (Bowman (2009)) permutation tests for significance of SNP effects as a heat map over the ordination, showing only ICOS mutations are of importance to carbamazepine drug-induced HSR. Row 2 Left: Biplot showing drug treated subjects (dark circles) versus placebo controls (open circles), plus importance of DIAPH1 carriage in determining weight loss response to drug. Middle: Simultaneous analysis of SNP, clinical, subject-scored and cellular pathway data across multiple scales in determining psychiatric disease U. Note neurological pathway 3 closely correlated with disease and a subject’s own assessment of anxiety. Being overweight has no impact. Right: Simultaneous analysis of two drug-induced adverse events (I versus S) showing that carriage of SNPs in the drug metabolism pathway are related to predisposition to AE ‘S’. Row 3 Left: Genetic dissection into two locus haplotypes determining drug induced SJS versus TEN. Note importance of ancestral 57.1 haplotype for SJS, and HLA Class II for TEN predisposition in separating cases and controls [11]. Middle: SVD of divergences interactions over HLA and Alu space in cancer cell line sample showing at least 8 hidden subtypes of causation. Right: Biplot of human disease D showing genetic correlates of disease as well as unexpected control heterogeneity on left. Row 4 Left: Plot of human disease D controls coloured by clinical centre of subject showing how controls’ genetics differs from center to center-confounding investigation of the causes of disease D. Middle: Network of epistatic links in drug induced bullous disorders [11]. Strong links indicate epistatically interacting loci in determining susceptibility. Vertically up the page=predisposition to SJS; Horizontally across the page=predisposition to TEN. Not just haplotype carriage is relevant to the diseases. Right: Simultaneous genetic dissection of multiple drug induced bullous disorders [11].