miRNA Expression in subtype Confirmed targets References SqCC AdC SCLC let-7 Dn     HMGA2, RAS, MYC, E2Fs, CDKs [24, 25, 54, 65, 77, 78, 80, 81, 105] miR-9     Up TGFBI, TRIM2, SIRT1, BTBD3 [24, 25, 54, 106] miR-17-92 cluster     Up p21, E2F, CCND1, PTEN, Rb, HIF-1α [40, 54] miR-31   Up   LATS2, PPP2R2A [10, 23, 46, 64, 65] miR-93     Up p21, FUS1 [10, 54, 111, 118] miR-95     Up SNX1 [25, 54, 119] miR-98     Up FUS1 [10, 54, 93, 118] miR-128     Up EGFR [45, 54] miR-130b Up     CSF-1, TP53INP1, RUNX3 [54, 64, 65] miR-139 Dn     ROCK2, FOXO1, CXCR4 [24, 64, 65, 123-125] miR-140   Dn   Sp1, BMP2 [25, 64] miR-143   Dn   ERK5, KRAS, Bcl-2, DNMT3A, ELK1 [23-25, 54, 64] miR-146b   Up   MMP16, TRAF6, IRAK1, [25, 54, 77, 78, 107] miR-149 Up     E-cadherin [10, 55, 65] miR-150   Dn   MUC4, P2RX7 [25, 54, 64] miR-155   Up   TAB2, FADD, RIP-1, IKKϵ, ET-1 [25, 54, 61, 77, 78, 107] miR-182   Up   FOXO1 [24, 54, 61, 64, 65, 77, 78, 80, 95, 120] miR-191   Up   CDK6, TIMP3, NDST1 [25, 54, 77, 78, 107] miR-192   Up   ERCC3, ERCC4, Rb1 [25, 107] miR-200a,b   Up   C-ets-1, Zeb1, ECM proteins, p38α [54, 64, 79, 127] miR-200c Up     C-ets-1, Zeb1, ECM proteins [54, 65, 77, 128] miR-203   Up   DeltaNp63, Smo [25, 77, 107] miR-205 Up     E2F1, Zeb1, Sip1 [10, 25, 65, 74, 75, 78, 93, 107] miR-218   Dn   RICTOR [24, 25, 64] miR-324-5p Up     Smo, Gli1 [10, 54, 65, 130] miR-375     Up IGF1R, SP1, LDHB, YAP1 [54, 64, 137-140] miR-423 Up     p21 [24, 65, 141] miR-429 Dn     ALDH1L2, PSAT1, ZEB1 [54, 65, 142] miR-486   Dn   CD40 [64, 65, 108] Note: Targets cited are confirmed by experiments

Table 2: miRNAs differentially expressed in histological subtypes of lung cancer.