| |
Unadjusted model |
|
Adjusted model |
| Metabolite |
β |
p |
β |
p |
padj1 |
Δ (%)2 |
| Acylcarnitines |
| C12 |
0.17 |
0.025 |
0.29 |
0.002 |
0.033 |
16.23 |
| C14:2 |
0.19 |
0.019 |
0.32 |
0.002 |
0.029 |
13.49 |
| C16 |
0.19 |
0.004 |
0.26 |
0.002 |
0.025 |
16.57 |
| C18 |
0.21 |
0.001 |
0.28 |
4.5×10-4 |
0.010 |
18.36 |
| C18:2 |
0.25 |
4.1×10-4 |
0.33 |
1.7×10-4 |
0.004 |
18.62 |
| C5 |
0.38 |
2.8×10-9 |
0.28 |
2.7×10-4 |
0.007 |
31.62 |
| Amino Acids |
| Glutamine |
0.17 |
0.001 |
0.22 |
0.001 |
0.011 |
12.70 |
| Biogenic Amines |
|
|
|
| Creatinine |
0.28 |
1.1×10-8 |
0.30 |
10-8 |
<10-4 |
21.42 |
| total DMA |
0.13 |
0.004 |
0.19 |
0.001 |
0.017 |
9.47 |
| Lyso-Phosphatidylcholines |
| lysoPC a C18:1 |
0.18 |
0.015 |
0.28 |
0.002 |
0.029 |
12.49 |
| lysoPC a C18:2 |
0.28 |
0.001 |
0.41 |
3.9×10-5 |
0.001 |
19.39 |
P values and regression coefficients (ß) derived from a linear regression analysis of log-transformed metabolite concentrations measured in 165 study participants (101
men, 64 women). All models were also additionally adjusted for age, waist-to-hip ratio, HDL cholesterol and smoking status
1 padj denotes the p value adjusted for multiple testing by the Westfall and Young Step-Down MaxT procedure with 10,000 permutations
2 ? denotes relative sex difference, defined as the difference in mean concentration between men and women, divided by the mean concentration in men |
