Formulation

Pharmacokinetic Parameters

Tmax (h)

Cmax (ng/ml)

AUC (ng.h/ml)

Kel (h-1)

t1/2 (h)

Oral

1.5

60.07

94.17

0.582

1.19

IN1

3

95.51

446.25*

0.164

4.22

IN5

3

90.32

406.85*

0.196

3.53

*p<0.05
Table 3: Pharmacokinetic parameters of oral tablet and nasal microspheres of Neostigmine Bromide.