| Pharmacokinetic parameter |
F 2 |
F 7 |
GLZ solution |
Dunn’s multiple comparison Test
P value |
| Cmax (ng/ml) |
1706.5 ± 165.3 |
1890. 1± 150.2 |
1875.6 ± 55.3 |
P> 0.05 F2 & F7
P> 0.05 F7& Solution
P > 0.05 F2 & solution |
| Tmax(h) |
8.02 ±1.02 |
6.48± 0.86 |
3.24± 0.58 |
P > 0.05 F2 & solution
P > 0.01 F7& solution
P> 0.05 F2& F7 |
| AUC0-24 (ng/ml/h) |
21741.3± 696.6 |
20464.5± 1326.7 |
8214.7 ± 403.1 |
P> 0.05 F2 & F7
P> 0.05, F2, F7 & Solution |
| AUC0-∞ (ng/ml/h) |
23135.2± 1819.2 |
21314.2± 1349.1 |
11393.6 ± 452.6 |
P> 0.001 F2, F7 & Solution |
| MRT (h) |
11.21 ±1.85 |
12.83± 1.32 |
9.85± 2.43 |
P > 0.05 F2, F7 & solution |
| Lag time (h) |
0.86 |
0.42 |
0.00 |
|
