% of non-ionized forms
Isoflavone
MW
p
Ka
a
log
P
b
logD
6.0
b
logD
7.4
b
pH 6.0
b
pH 7.4
b
Genistein
270
6.51
3.08
2.98
2.22
80.1
13.4
DHG
272
7.52
2.73
2.72
2.61
98.7
75.6
Daidzein
254
7.01
2.73
2.61
1.77
75.0
10.4
DHD
256
7.71
2.38
2.37
2.23
98.3
70.2
DHG, dihydrogenistein; DHD, dihydrodaidzein; MW, molecular weight
a
SciFinder Scholar.
b
Marvin Sketch (
http://www.chemaxon.com/marvin
).
Table 1:
Physicochemical properties of test compounds. Molecular weights, estimated pKa, logP and logD and presence of non-ionized forms.