| |
One-compartment model |
Two-compartment model |
Three-compartment model |
| Parameters |
XlSimEst*# |
WinNonlin |
ADAPT II* |
XlSimEst*# |
WinNonlin |
ADAPT II* |
XlSimEst*# |
WinNonlin |
ADAPT II* |
| K10 |
0.0079 ± 0.0011 |
0.0079 ± 0.0011 |
0.0079 ± 0.0011 |
0.0071 ± 0.0004 |
0.0071 ± 0.0004 |
0.0071 ± 0.0004 |
0.0067 ± 0.0010 |
0.0067 ± 0.0009 |
0.0067 ± 0.0009 |
| K12 |
|
|
|
0.0218 ± 0.0021 |
0.0219 ± 0.0021 |
0.0219 ± 0.0021 |
0.0194 ± 0.0061 |
0.0195 ± 0.0063 |
0.0196 ± 0.0062 |
| K21 |
|
|
|
0.0222 ± 0.0028 |
0.0222 ± 0.0028 |
0.0222 ± 0.0028 |
0.0632 ± 0.0436 |
0.0632 ± 0.0457 |
0.0635 ± 0.0457 |
| K13 |
|
|
|
|
|
|
0.0121 ± 0.0073 |
0.0121 ± 0.0073 |
0.0123 ± 0.0073 |
| K31 |
|
|
|
|
|
|
0.0117 ± 0.0070 |
0.0117 ± 0.0070 |
0.0118 ± 0.0070 |
| C0 |
1.4028 ± 0.0827 |
1.4027 ± 0.0827 |
1.4027 ± 0.0827 |
1.8408 ± 0.0412 |
1.8402 ± 0.0412 |
1.8402 ± 0.0412 |
1.9271 ± 0.0754 |
1.9307 ± 0.0778 |
1.9311 ± 0.0769 |
| Diagnostics |
|
|
|
|
|
|
|
|
|
| R2 |
0.9135 |
0.9135 |
0.9135 |
0.9974 |
0.9974 |
0.9974 |
0.9985 |
0.9985 |
0.9985 |
| SS |
0.2598 |
0.2598 |
0.2598 |
0.0065 |
0.0065 |
0.0065 |
0.0037 |
0.0037 |
0.0037 |
| SE |
0.1471 |
0.1471 |
0.1471 |
0.0255 |
0.0255 |
0.0255 |
0.0214 |
0.0214 |
0.0214 |
| AIC |
-14.87 |
-14.87 |
-14.87 |
-62.53 |
-62.53 |
-62.53 |
-66.47 |
-66.47 |
-66.47 |
| SC |
-13.59 |
-13.59 |
-13.59 |
-59.98 |
-59.98 |
-59.98 |
-62.64 |
-62.64 |
-62.64 |
| *Initial values were arbitrary assigned: K10 = K12 = K21 = K13 = K31 = 0.01; C0=1. Weighting scheme (W=1) was used in all cases. # step size of 5 (mins) was used for numerical integration. |
|
|