Dataset
Num. of cases with/without a pattern
Num. of controls with/without a pattern
Unadjusted
P
value
Adjusted
P
value
Odds Ratio (Confidence Interval)
Marker patterns
Alcohol Dependence (12 patterns)
71/207
37/268
3.19×10
-5
0.007
2.48 (1.60-3.85)
M5_C + D6_AA
89/181
57/247
1.00×10
-4
0.013
2.11 (1.44-3.11)
D4_AA + K4_TT
62/215
31/276
5.13×10
-5
0.014
2.57 (1.61-4.09)
M2_A + D6_AA
60/218
29/277
4.87×10
-5
0.014
2.63 (1.63-4.23)
M3_A + D6_AA
109/163
75/215
3.00×10
-4
0.024
1.92 (1.34-2.74)
D6_AA + K6_CC
76/200
45/259
2.00×10
-4
0.03
2.19 (1.45-3.30)
M7_G + D9_AA
46/232
19/285
8.25×10
-5
0.032
2.97 (1.70-5.21)
M7_AG + D6_AA
60/216
31/276
1.00×10
-4
0.034
2.47 (1.55-3.95)
M2_A + D7_TT
87/188
57/250
3.00×10
-4
0.034
2.03 (1.38-2.98)
M2_A + D9_AA
52/225
24/280
1.00×10
-5
0.038
2.70 (1.61-4.51)
M7_G + D7_TT
52/226
24/280
1.00×10
-4
0.04
2.68 (1.60-4.49)
M7_G + D6_AA
45/232
19/285
1.00×10
-4
0.049
2.91 (1.66-5.11)
M7_AG + D7_TT
Cocaine Dependence (4 patterns)
39/102
37/268
5.13×10
-5
0.001
2.77 (1.67-4.59)
M5_C + D6_AA
37/103
37/268
2.00×10
-4
0.037
2.60 (1.56-4.33)
M5_C + D7_TT
33/107
31/276
2.00×10
-4
0.043
2.75 (1.60-4.71)
M2_A + D7_TT
19/120
11/293
9.67×10
-5
0.047
4.22 (1.95-9.13)
M8_CC + K3_TT
Opioid Dependence (18 patterns)
33/44
57/249
7.74×10
-6
0.0004
3.28 (1.92-5.60)
M2_A + D9_AA
20/58
24/282
1.06×10
-5
0.002
4.05 (2.10-7.82)
M2_GA + D6_AA
22/56
30/275
2.45×10
-5
0.005
3.60 (1.94-6.70)
M11_CC + K3_TT
22/55
31/275
2.87×10
-5
0.005
3.55 (1.88-6.46)
M12_TT + K3_TT
30/47
55/250
8.25×10
-5
0.005
2.90 (1.69-4.99)
M3_A + D9_AA
13/63
11/292
1.70×10
-5
0.006
5.48 (2.35-12.79)
M8_CC + K3_TT
22/56
31/275
3.74×10
-5
0.007
3.49 (1.88-6.46)
M2_A + D6_AA
27/50
47/259
9.17×10
-5
0.01
2.98 (1.70-5.22)
M2_GA+ D9_AA
19/59
24/281
3.94×10
-5
0.01
3.77 (1.94-7.33)
M3_CA + D6_AA
18/60
22/284
4.15×10
-5
0.012
3.87 (1.96-7.66)
M13_GG + K3_TT
19/59
25/281
6.33×10
-5
0.016
3.62 (1.87-7.00)
M2_GA + D7_AA
20/58
28/278
8.70×10
-5
0.02
3.42 (1.81-6.49)
D4_AA + K3_TT
18/60
23/282
7.83×10
-5
0.022
3.68 (1.87-7.24)
M3_CA + D7_TT
26/51
46/259
2.00×10
-4
0.023
2.87 (1.63-5.06)
M3_CA+ D9_AA
21/57
31/275
1.00×10
-4
0.024
3.27 (1.75-6.09)
M2_A + D7_TT
18/60
24/282
1.00×10
-4
0.034
3.52 (1.80-6.90)
M9_CC + K3_TT
20/58
29/276
1.00×10
-4
0.035
3.28 (1.74-6.20)
M3_A + D6_AA
25/53
44/262
3.00×10
-4
0.041
2.81 (1.58-4.98)
M2_A + D4_AA
Dataset: genotype data of controls and alcohol, cocaine, or opioid dependent cases.
Table 2:
Significant marker patterns identified in two-locus marker-based gene-gene interaction analyses.
