| 
      Data are presented as means ± SEM, and p value. ANOVA with repeated measures was used to compare the changes in SBP, DBP, HR, MAP and RPP values.
    Bonferroni’s multiple comparison tests were used to make intragroup comparisons. Comparison PI-L, D&E, PII-L&D, PIII-L&E, PIV-D&E
        | Parameter | Lidocaine | Diltiazem | Esmolol | PI | PII | PIII | PIV |  
        | SBP (mmHg) | 136.7 ± 1.29 | 133.1 ± 1.29 | 131.9 ± 1.39 | 0.0293 | 0.0487 | 0.0125 | 0.5291 |  
        | DBP (mmHg) | 91.80 ± 0.88 | 85.15 ± 0.85 | 82.63 ± 0.83 | P<0.0001 | P<0.0001 | P<0.0001 | 0.0367 |  
        | HR (per min) | 101.1 ± 1.31 | 89.90 ± 1.08 | 91.40 ± 1.19 | P<0.0001 | P<0.0001 | P<0.0001 | 0.3529 |  
        | MAP (mmHg) | 106.8 ± 0.70 | 101.1 ± 0.80 | 99.04 ± 0.65 | P<0.0001 | P<0.0001 | P<0.0001 | 0.0473 |  
        | RPP | 13810 ± 200.5 | 11980 ± 205.2 | 12060 ± 213.7 | P<0.0001 | P<0.0001 | P<0.0001 | 0.7704 |  |