| Cpds |
X |
Y |
MW |
OBAV, % |
cLogPb |
| 2.8 |
NA |
NA |
354.7 |
1 |
-0.73 |
| 5.1 |
Ph |
H |
470.9 |
0 |
5.25 |
| 5.2 |
4-F-Ph |
H |
488.9 |
2 |
5.30 |
| 5.3 |
3-Br-4-MeO-Ph |
H |
579.8 |
0 |
5.74 |
| 5.4 |
3-furyl |
H |
460.8 |
0 |
4.41 |
| 5.5 |
4-pyridyl |
H |
471.9 |
12 |
3.76 |
| 5.6 |
2-pyridyl |
H |
471.9 |
6 |
3.76 |
| 5.7 |
H |
CH2OH |
424.8 |
11 |
2.67 |
| 5.8 |
H |
CH2OAc |
466.9 |
10 |
3.57 |
| 5.9 |
H |
CH2OCO2Me |
482.9 |
14 |
3.54 |
| 5.10 |
H |
CH2N3 |
449.8 |
13 |
3.58 |
| 5.11 |
H |
CH2NH2 |
423.8 |
4 |
2.72 |
aOBAV determined by measuring urinary excretion of 2.8 following oral
administration of the prodrug vs i.v. administration of 2.8; bADME Boxes version
3.5 (Pharma Algorithm, Toronto, Canada) was used |
