Figure 6 : The effect of imeglimin (1.0, 2.5, 5.0, and 10 mmol•L-1) on gluconeogenesis was studied in liver slices from 48 h fasted non-diabetic ZDF rats as described in Methods. Results are the mean values n = 5 for controls and each dose of imeglimin. Imeglimin significantly inhibited glucose production (*P<0.01) in a dose-dependent manner.